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1

Studies on the mechanism of action of omeprazole

David J. Keeling, Colin Fallowfield, Kevin J. Milliner, Stephen K. Tingley, Robert J. Ife, Anthony H. Underwood

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 806 KB

english, 1985

2

ChemInform Abstract: Diastereoselective Synthesis, Activity and Chiral Stability of Cyclic Alkoxyketone Inhibitors of Cathepsin K.

Ashley E. Fenwick, Andrew D. Gribble, Robert J. Ife, Nichola Stevens, Jason Witherington

Journal:

Year:

2001

File:

PDF, 31 KB

2001

3

ChemInform Abstract: Lipoprotein-Associated PLA2 Inhibition — A Novel, Non-Lipid Lowering Strategy for Atherosclerosis Therapy

Colin A. Leach, Deirdre M. B. Hickey, Robert J. Ife, Colin H. Macphee, Stephen A. Smith, David G. Tew

Journal:

Year:

2001

File:

PDF, 28 KB

2001

4

ChemInform Abstract: Conformationally Restricted Indolopiperidine Derivatives as Potent CCR2B Receptor Antagonists.

Jason Witherington, Vincent Bordas, Dave G. Cooper, Ian T. Forbes, Andrew D. Gribble, Robert J. Ife, Theo Berkhout, Jayneeta Gohil, Pieter H. E. Groot

Journal:

Year:

2001

Language:

english

File:

PDF, 31 KB

english, 2001

5

5-Aryl-pyrazolo[3,4-b]pyridazines: Potent Inhibitors of Glycogen Synthase Kinase-3 (GSK-3).

Jason Witherington, Vincent Bordas, David Haigh, Deirdre M. B. Hickey, Robert J. Ife, Anthony D. Rawlings, Brian P. Slingsby, David G. Smith, Robert W. Ward

Journal:

Year:

2003

Language:

english

File:

PDF, 113 KB

english, 2003

6

5-Aryl-pyrazolo[3,4-b]pyridines: Potent Inhibitors of Glycogen Synthase Kinase-3 (GSK-3).

Jason Witherington, Vincent Bordas, Stephen L. Garland, Deirdre M. B. Hickey, Robert J. Ife, John Liddle, Martin Saunders, David G. Smith, Robert W. Ward

Journal:

Year:

2003

Language:

english

File:

PDF, 121 KB

english, 2003

7

Iodobolpyramine and other iodinated derivatives as ligands for detecting histamine H1 receptors

Robert C Blakemore, C.Robin Ganellin, Monique Garbarg, Claude Gros, Robert J Ife, Marie Körner, Martial Ruat, Jean-Charles Schwartz, Wasyl Tertiuk, Colin J Theobald

Journal:

European Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 1.28 MB

english, 1987

8

Non-basic histamine H1-antagonists. I. Synthesis and biological evaluation of some substituted 2-(2-pyridylaminoalkylamino) pyrimidones and related compounds

Robert J Ife, Keith W Catchpole, Graham J Durant, C Robin Ganellin, Carol A Harvey, Malcolm L Meeson, David A.A Owen, Michael E Parsons, Brian P Slingsby, Colin J Theobald

Journal:

European Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.04 MB

english, 1989

9

Identification of a sulfonamide series of CCR2 antagonists

Simon Peace, Joanne Philp, Carl Brooks, Val Piercy, Kitty Moores, Chris Smethurst, Steve Watson, Simon Gaines, Mara Zippoli, Claudette Mookherjee, Robert Ife

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 511 KB

english, 2010

10

2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2

Helen F. Boyd, Sean T. Flynn, Deirdre M.B. Hickey, Robert J. Ife, Martin Jones, Colin A. Leach, Colin H. Macphee, Kevin J. Milliner, D.Anthony Rawlings, Brian P. Slingsby, Stephen A. Smith, Ian G. Sta

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 122 KB

english, 2000

11

CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound

Ian T Forbes, David G Cooper, Emma K Dodds, Deirdre M.B Hickey, Robert J Ife, Malcolm Meeson, Martin Stockley, Theo A Berkhout, Jayneeta Gohil, Pieter H.E Groot, Kitty Moores

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 144 KB

english, 2000

12

N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2

Helen F. Boyd, Stephen C.M. Fell, Sean T. Flynn, Deirdre M.B. Hickey, Robert J. Ife, Colin A. Leach, Colin H. Macphee, Kevin J. Milliner, Kitty E. Moores, Ivan L. Pinto, Rod A. Porter, D.Anthony Rawli

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 164 KB

english, 2000

13

Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K

Ashley E. Fenwick, Bénédicte Garnier, Andrew D. Gribble, Robert J. Ife, Anthony D. Rawlings, Jason Witherington

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 199 KB

english, 2001

14

Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K

Ashley E Fenwick, Andrew D Gribble, Robert J Ife, Nichola Stevens, Jason Witherington

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 158 KB

english, 2001

15

3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)

David G. Smith, Marianne Buffet, Ashley E. Fenwick, David Haigh, Robert J. Ife, Martin Saunders, Brian P. Slingsby, Rachel Stacey, Robert W. Ward

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 196 KB

english, 2001

16

The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2

Helen F. Boyd, Beverley Hammond, Deirdre M.B. Hickey, Robert J. Ife, Colin A. Leach, V.Ann Lewis, Colin H. Macphee, Kevin J. Milliner, Ivan L. Pinto, Stephen A. Smith, Ian G. Stansfield, Colin J. Theo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 124 KB

english, 2001

17

1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A2

Jackie C. Bloomer, Helen F. Boyd, Deirdre M.B. Hickey, Robert J. Ife, Colin A. Leach, Colin H. Macphee, Kevin J. Milliner, Ivan L. Pinto, D.Anthony Rawlings, Stephen A. Smith, Ian G. Stansfield, Steve

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 148 KB

english, 2001

18

Conformationally Restricted Indolopiperidine Derivatives as Potent CCR2B Receptor Antagonists

Jason Witherington, Vincent Bordas, Dave G. Cooper, Ian T. Forbes, Andrew D. Gribble, Robert J. Ife, Theo Berkhout, Jayneeta Gohil, Pieter H.E. Groot

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 140 KB

english, 2001

19

Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones

Helen F. Boyd, Stephen C.M. Fell, Deirdre M.B. Hickey, Robert J. Ife, Colin A. Leach, Colin H. Macphee, Kevin J. Milliner, Ivan L. Pinto, D.Anthony Rawlings, Stephen A. Smith, Ian G. Stansfield, Steve

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 127 KB

english, 2002

20

The discovery of SB-435495: A potent, orally active inhibitor of lipoprotein-Associated phospholipase A2 for evaluation in man

Josie A. Blackie, Jackie C. Bloomer, Murray J.B. Brown, Hung-Yuan Cheng, Richard L. Elliott, Beverley Hammond, Deirdre M.B. Hickey, Robert J. Ife, Colin A. Leach, V.Ann Lewis, Colin H. Macphee, Kevin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 110 KB

english, 2002

21

Identification of a novel series of selective 5-HT7 receptor antagonists

Ian T. Forbes, David G. Cooper, Emma K. Dodds, Sara E. Douglas, Andrew D. Gribble, Robert J. Ife, Andrew P. Lightfoot, Malcolm Meeson, Lorraine P. Campbell, Tanya Coleman, Graham J. Riley, David R. Th

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 151 KB

english, 2003

22

The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives

David G. Smith, Andrew D. Gribble, David Haigh, Robert J. Ife, Patrick Lavery, Peter Skett, Brian P. Slingsby, Rachel Stacey, Robert W. Ward, Andrew West

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 367 KB

english, 1999

23

A synthesis of some pyridinylpyrimidines from ketenedithioacetals

Ruth B. Katz, Michael B. Mitchell, Peter G. Sammes, Robert J. Ife

Journal:

Year:

1989

Language:

english

File:

PDF, 691 KB

english, 1989

24

SB-656104-A: A novel 5-HT7 receptor antagonist with improved In vivo properties

Ian T. Forbes, Sara Douglas, Andrew D. Gribble, Robert J. Ife, Andrew P. Lightfoot, Ashley E. Garner, Graham J. Riley, Phillip Jeffrey, Alexander J. Stevens, Tania O. Stean, David R. Thomas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 130 KB

english, 2002

25

The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2

Josie A. Blackie, Jackie C. Bloomer, Murray J.B. Brown, Hung-Yuan Cheng, Beverley Hammond, Deirdre M.B. Hickey, Robert J. Ife, Colin A. Leach, V.Ann Lewis, Colin H. Macphee, Kevin J. Milliner, Kitty E

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 136 KB

english, 2003

26

5-Aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)

Jason Witherington, Vincent Bordas, Stephen L Garland, Deirdre M.B Hickey, Robert J Ife, John Liddle, Martin Saunders, David G Smith, Robert W Ward

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 171 KB

english, 2003

27

5-Aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)

Jason Witherington, Vincent Bordas, David Haigh, Deirdre M.B Hickey, Robert J Ife, Anthony D Rawlings, Brian P Slingsby, David G Smith, Robert W Ward

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 188 KB

english, 2003

28

CCR2: Characterization of the Antagonist Binding Site from a Combined Receptor Modeling/Mutagenesis Approach

Berkhout, Theo A., Blaney, Frank E., Bridges, Angela M., Cooper, David G., Forbes, Ian T., Gribble, Andrew D., Groot, Pieter H. E., Hardy, Adam, Ife, Robert J., Kaur, Rejbinder

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 1.22 MB

english, 2003

29

Horizontal or vertical? an evaluation of patient preferences for reduction mammaplasty scars

Amy M. Sprole, Ife Adepoju, Jeffrey Ascherman, Lloyd B. Gayle, Robert T. Grant, Mia Talmor

Journal:

Aesthetic Surgery Journal

Year:

2007

Language:

english

File:

PDF, 114 KB

english, 2007

30

Lipoprotein-associated PLA2 inhibition — a novel, non-lipid lowering strategy for atherosclerosis therapy

Colin A Leach, Deirdre M.B Hickey, Robert J Ife, Colin H Macphee, Stephen A Smith, David G Tew

Journal:

Year:

2001

Language:

english

File:

PDF, 173 KB

english, 2001

31

2-[[(4-Amino-2-pyridyl)methyl]sulfinyl]benzimidazole H+/K+-ATPase inhibitors. The relationship between pyridine basicity, stability, and activity

Ife, Robert J., Dyke, Catherine A., Keeling, David J., Meenan, Eugene, Meeson, Malcolm L., Parsons, Michael E., Price, Carolyn A., Theobald, Colin J., Underwood, Anthony H.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 975 KB

english, 1989

32

Reversible inhibitors of the gastric (H+/K+)-ATPase. 3. 3-Substituted-4-(phenylamino)quinolines

Ife, Robert J., Brown, Thomas H., Keeling, David J., Leach, Colin A., Meeson, Malcolm L., Parsons, Michael E., Reavill, David R., Theobald, Colin J., Wiggall, Kenneth J.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.21 MB

english, 1992

33

Characterisation of the effects of anthranilic and (indanyloxy) acetic acid derivatives on chloride transport in membrane vesicles

Andrew J. Pope, Stewart K. Richardson, Robert J. Ife, David J. Keeling

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1991

Language:

english

File:

PDF, 800 KB

english, 1991

34

Properties of the reversible, K+-competitive inhibitor of the gastric (H+/K+)-ATPase, SK&F 97574. I. In vitro activity

Andrew J. Pope, Mark K. Boehm, Colin Leach, Robert J. Ife, David Keeling, Michael E. Parsons

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 783 KB

english, 1995

35

properties of the reversible, K+-competitive inhibitor of the gastric H+/K+)-ATPase, SK&F 97574. II. Pharmacological properties

Michael E. Parsons, Beverly Rushant, Tony C. Rasmussen, Colin Leach, Robert J. Ife, Stefan Postius, Andrew J. Pope

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 717 KB

english, 1995

36

[125I]iodobolpyramine, a highly sensitive probe for histamine H1-receptors in guinea-pig brain

Marie Korner, Marie-Louise Bouthenet, C Robin Ganellin, Monique Garbarg, Claude Gros, Robert J Ife, Nicole Sales, Jean-Charles Schwartz

Journal:

European Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 741 KB

english, 1986

37

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. 2. Synthesis and Evaluation of (3 R ,5 S )-ω-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in Vitro and in Vivo

Gribble, Andrew D., Ife, Robert J., Shaw, Antony, McNair, David, Novelli, Christine E., Bakewell, Susan, Shah, Virendra P., Dolle, Roland E., Groot, Pieter H., Pearce, Nigel, Yates, John, Tew, David,

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 275 KB

english, 1998

38

Reversible inhibitors of the gastric (H+/K+)-ATPase. 2. 1-Arylpyrrolo[3,2-c]quinolines: effect of the 4-substituent

Leach, Colin A., Brown, Thomas H., Ife, Robert J., Keeling, David J., Laing, Shiona M., Parsons, Michael E., Price, Carolyn A., Wiggall, Kenneth J.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.07 MB

english, 1992

39

Swern oxidation of diaziridines to diazirines

Richardson, Stewart K., Ife, Robert J.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1989

Language:

english

File:

PDF, 175 KB

english, 1989

40

Reversible inhibitors of the gastric (H+/K+)-ATPase. 1. 1-Aryl-4-methylpyrrolo[3,2-c]quinolines as conformationally restrained analogs of 4-(arylamino)quinolines

Brown, Thomas H., Ife, Robert J., Keeling, David J., Laing, Shiona M., Leach, Colin A., Parsons, Michael E., Price, Carolyn A., Reavill, David R., Wiggall, Kenneth J.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 935 KB

english, 1990

41

Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 4. Identification of an Inhibitor with an Intermediate Duration of Action

Leach, Colin A., Brown, Thomas H., Ife, Robert J., Keeling, David J., Parsons, Michael E., Theobald, Colin J., Wiggall, Kenneth J.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.70 MB

english, 1995

42

Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 5. Substituted 2,4-Diaminoquinazolines and Thienopyrimidines

Ife, Robert J., Brown, Thomas H., Blurton, Peter, Keeling, David J., Leach, Colin A., Meeson, Malcolm L., Parsons, Michael E., Theobald, Colin J.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.31 MB

english, 1995

43

The shikimate pathway. Part V. Chorismic acid and chorismate mutase

Ife, Robert J., Ball, Leslie F., Lowe, Peter, Haslam, Edwin

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1976

Language:

english

File:

PDF, 1.19 MB

english, 1976

44

Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor

MACPHEE, Colin H., MOORES, Kitty E., BOYD, Helen F., DHANAK, Dash, IFE, Robert J., LEACH, Colin A., LEAKE, David S., MILLINER, Kevin J., PATTERSON, Rebecca A., SUCKLING, Keith E., TEW, David G., HICKE

Journal:

Biochemical Journal

Year:

1999

Language:

english

File:

PDF, 178 KB

english, 1999

45

Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor

MACPHEE, Colin H., MOORES, Kitty E., BOYD, Helen F., DHANAK, Dash, IFE, Robert J., LEACH, Colin A., LEAKE, David S., MILLINER, Kevin J., PATTERSON, Rebecca A., SUCKLING, Keith E., TEW, David G., HICKE

Journal:

Biochemical Journal

Year:

1999

Language:

english

File:

PDF, 178 KB

english, 1999

46

Photoaffinity inactivation of the gastric (H + + K + )-ATPase at a site involved in ion translocation

FALLOWFIELD, COLIN, LAWRIE, KENNETH W. M., SAUNDERS, DAVID, IFE, ROBERT J., KEELING, DAVID J.

Journal:

Biochemical Society Transactions

Year:

1988

Language:

english

File:

PDF, 138 KB

english, 1988

47

[Annual Reports in Medicinal Chemistry] Volume 25 || Chapter 17. Agents for the Treatment of Peptic Ulcer Dlsease

Year:

1990

Language:

english

File:

PDF, 806 KB

english, 1990

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